Mitoxantrone slowed progression of disability and reduced relapses in multiple sclerosis.
نویسنده
چکیده
and commentary also appear in ACP Journal Club. 148 Volume 8 September/October 2003 EBM Therapeutics www.evidence-basedmedicine.com group.bmj.com on April 11, 2017 Published by http://ebm.bmj.com/ Downloaded from
منابع مشابه
Prevention of autoimmune attack and disease progression in multiple sclerosis: current therapies and future prospects.
Multiple sclerosis (MS) is an important cause of progressive neurological disability, typically commencing in early adulthood. There is a need for safe and effective therapy to prevent the progressive central nervous system (CNS) damage and resultant disability that characterize the disease course. Increasing evidence supports a chronic autoimmune basis for CNS damage in MS. In the present stud...
متن کاملMitoxantrone reduced disability in Iranian patients with multiple sclerosis.
BACKGROUND Multiple sclerosis is a leading cause of disability in young adults. Mitoxantrone has recently been shown to be effective in ameliorating multiple sclerosis activity and reducing the relapse rate. This study aimed to assess the efficacy of mitoxantrone on disease activity and decreasing relapse rate in patients with multiple sclerosis in Iran. METHODS This was a clinical trial on p...
متن کاملModifiable factors influencing relapses and disability in multiple sclerosis.
A growing body of literature indicates that the natural course of multiple sclerosis can be influenced by a number of factors. Strong evidence suggests that relapses can be triggered by infections, the postpartum period and stressful life events. Vaccinations against influenza, hepatitis B and tetanus appear to be safe. Surgery, general and epidural anaesthesia, and physical trauma are not asso...
متن کاملP67: The Effect of Melatonin on EDSS and Fatigue in Multiple Sclerosis
Multiple Sclerosisis (MS) is a common demylinating disease of CNS that inflammation and stress oxidative processes have an important role in clinical courses and progression of it. Suppressing the antigen-presenting capacity of glial cells seems a convinient way of reducing inflammatory activity in MS. The aim of the present study was to determine the anti-inflamatory effects of Melatonin on fa...
متن کاملEarly onset cardiotoxicity associated with mitoxantrone in patients with multiple sclerosis.
M sclerosis (MS) is an autoimmune disease, involving predominantly the white matter of the brain and spinal cord. Approximately 85% of patients initially experience one or more relapses followed by complete or incomplete recovery; this clinical pattern is called the relapsing–remitting phase. Over 10 years, roughly 50% of these patients experience a transition to the secondary progressive phase...
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عنوان ژورنال:
- ACP journal club
دوره 139 2 شماره
صفحات -
تاریخ انتشار 2003